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Levothyroxine
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa682461
Pregnancy categoryUS: A (No risk in human studies)
Routes of administrationby mouth, intravenous
ATC codeH03AA01 ( WHO )
Legal status
Legal statusUS: ℞-only
Pharmacokinetic data
Bioavailability40-80% [1]
Metabolismmainly in liver, kidneys, brain and muscles
Elimination half-lifeca. 7 days (in hyperthyroidism 3–4 days, in hypothyroidism 9–10 days)
Excretionfeces and urine

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Each subsequent course may be started as early as 30 days after the previous course and after pregnancy has been excluded.

In the event of overdose, appropriate supportive measures should be employed.

The majority of patients who are going to respond will respond to the first course of therapy, and 3 courses should constitute an adequate therapeutic trial.

Talk to your doctor if you have concerns about this risk.

The FDA categorizes medications based on safety for use during pregnancy.

Therefore the recommended duration of treatment should not be exceeded see section 4.

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